❗️Let’s talk about Granulomas.
Granuloma is a non-allergic chronic inflammatory reaction that is mainly composed of multinucleated giant cells.
They usually go through “phases”: protein adsorption, macrophage adhesion, macrophage fusion, and crosstalk.
Granulomas following dermal fillers will usually be defined as cystic granulomas.
These differ to “nodules”, as they usually occur months’ after injection (not weeks’), and are not related to poor technique. Factors that can influence granulomas include injected volume 💧 , repeat injections💉, impurities❗️, particle size✔️, surface smoothness and surface change of the filler✅, as well as hydrophilicity💯. They can occur everywhere where you’ve had filler injected, not just localised to one area.
‼️Treatment may involve dissolving the filler along with steroids. If that is unsuccessful, surgery may be needed. However, there is no guarantee it won’t come back after surgery, if it’s not completely removed, as they don’t have defined borders.
Read more here: https://dx.doi.org/10.5999%2Faps.2015.42.2.232